|
New York
Mesotherapy,
How It
Works
Mesoporation
is a complex process that allows introduction
of mesotherapy and any other drugs into the tissue at depths equivalent
to the
mesotherapy injections. The delivery time required is between 10 20
minutes,
depending on the size of treated area. For example, face and neck
treatment
would take 15 minutes and cellulite, treatment about 30 minutes.
The depth of penetration ranges from very superficial 2-3 mm
up to a few centimeters.
Mesoporation is a new, no-needle treatment, stemming
from
iontophoresis. It delivers 99% of the prepared mesotherapy formulation
at the
depth of 1 centimeter and approximately 65% at the depth of 6
centimeters. In
contrast, traditional iontophoresis delivers only about 10% of the
product at
the depth of 1 cm.
Mesoporation is a novel
and unique method developed exclusively
for mesotherapy treatment and it is based on 4 modalities:
1.
Electroporation.
2. Electro repulsion
3. Mechanical pressure
4. PH gradient
Electroporation
Electroporation
is a process of a cellular membrane reorganization
in response to electrical impulses delivered by an active electrode.
The
impulse creates temporary, watery channels - mesopores- in the cellular
membrane.
The drug molecules can then penetrate the tissue through these channels.
The
process is possible due to the specific action on
the
fatty acids, which are an integral part of the epidermis and any other
tissue. When
a positively charged electrode touches the skin, a number of channels -
mesopores-are created.
Under specific electric impulse the lipid layer can
be rearranged
and new aqueous pathways can be formed through the stratum corneum. The
process
affects nonpolar fatty acid tales.
Rearranging the non-polar fatty acid tails leads to
creation
of temporary channels - mesopores. These channels are used for water
and
non-water soluble substances to be delivered through the skin barrier
and deep
into the tissue. We call them mesopores.
Electrorepulsion
The positively charged drug is repulsed by positively
charged
electrode into the tissue through the mesopores. Once those pathways
are
created the door to skin and body is Most of the mesotherapy drugs are
positively charged. open. In case of negatively charged drug the
polarity of electrodes
can be reversed. The electrode acts also as a dispenser (dispenser
electrode)
of the delivered solutions. The product has a positive charge, the
current
coming into the dispenser electrode has a positive charge and when they
meet
the product is repulsed through the mesopores. Because of the nature of
the
mesopores, both iones and molecules are diffused into the skin.
Additional driving force is a negatively charged
grounding
electrode placed in opposite geometry from the treatment area.
Mechanical
pressure It relates to the mechanical pressure applied to the skin by a
performing treatment person. The mechanical pressure is exerted through
the
product delivering electrode. The pressure pushes the drugs through the
mesopores
and into the tissue. The combination of electroporation,
electrorepulsion, and mechanical
pressure allows to deliver a large amount of substances.
It refers to electro osmosis and pH gradients. The
isoelectric
point of the skin is -4. Under physiological conditions, with the
surface of
skin buffered at or near 7.4, the electro osmosis favors positively
charged molecules.
Drugs’ negative polarity is not a problem. Prior to
mesoporation,
all of the mesotherapy or any other drugs or substances require to be
mixed
with the special carriers in order to be delivered. Those carriers are
an integral
part of the mesoporation technology and act as the vehicle carrying
drugs
through the stratum corneum.
Mesoporation device is an important milestone in
no-needle
drug delivery.
It can be used for rejuvenation, wrinkles, fat
deposits, love
handles, cellulites, second chin, bleaching, acne and other skin
problems,
stimulation of collagen and elastin, tissue lifts and any other
treatment
involving topical or injectable drugs. That kind of medical platform
can be used
for a follow up skin treatment after the face lift or any other
cosmetic
surgery. Mesoporation allows for effective delivery of any drug or any
formulation depending on the desired effect. It complements lasers,
dermabrasion,
Velasmooth, needle mesotherapy and any other treatment.
Drugs delivered by the mesoporation cause no
irritation and
no tissue reaction (unless there is an allergy to any formulation
component).
Mesoporation is a process developed by Microlab
Biomedical,
an Italian Bioengineering Company. Its product called “Mesoderm” has
recently
received FDA approval and as a class III device. It can only be
purchased by
licensed physicians. |
New York, NY 10028 
